Meanwhile Shuba Srinivasan ( Shruti Haasan) researched that Bodhidharma can be brought back if his sample of DNA is matched with another sample of DNA whom she finds it out as Aravind (Suriya) a descendant of Bodhidharma. This disease was the one which occurred during the time of Bodhidharma in China. Dong Lee starts this operation by injecting a virus into a street dog. Later in the modern day China, Dong Lee ( Johnny Tri Nguyen) is given the task of starting the biowar against India which is called the operation red.
However after few years,when he expressed his desire to leave, the people poisoned and buried him near the temple, believing that their place would be disease free if he's buried there.
He taught them how to cure many diseases, taught them martial arts, and the skill of hypnotising people. Later when he cured an unknown disease and fought against some people who ill treated villagers there, the people of China began to respect him very much. Initially the people in China treated him as an inferior. One day, he is sent to China by the gurumatha. Be it medicine or martial arts or genetics, he is the best. The film starts with Bodhidharma ( Suriya), a Pallava prince, who is an expert at all big things. Bright Eyes is Caesar's mother who was captured in Africa and was experimented on and later killed protecting her child. Rocket is a dominant chimp at the ape sanctuary, until Caesar overthrows him, then he becomes a loyal follower of Caesar.
John Lithgow as Charles Rodman, Will's Alzheimer's infected father who has improved after Will gave him the ALZ-112 and has grown a strong bond with Caesar.Andy Serkis as Caesar, a highly intelligent chimpanzee who has inherited the ALZ-112 from his mother while they were testing her, and is eventually brought up by Will.James Franco was cast after talks with Tobey Maguire broke down. Will Rodman, a scientist who is trying to cure his father's Alzheimer's Disease by testing it on chimps.